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The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose.

Abstract:

We examined the carbohydrate-binding potential of the C-type lectin-like receptor Dectin-2 (Clecf4n). The carbohydrate-recognition domain (CRD) of Dectin-2 exhibited cation-dependent mannose/fucose-like lectin activity, with an IC(50) for mannose of approximately 20 mM compared to an IC(50) of 1.5 mM for the macrophage mannose receptor when assayed by similar methodology. The extracellular domain of Dectin-2 exhibited binding to live Candida albicans and the Saccharomyces-derived particle zym...

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Publication status:
Published

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Publisher copy:
10.1093/glycob/cwj077

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Journal:
Glycobiology More from this journal
Volume:
16
Issue:
5
Pages:
422-430
Publication date:
2006-05-01
DOI:
EISSN:
1460-2423
ISSN:
0959-6658
Language:
English
Keywords:
Pubs id:
pubs:26663
UUID:
uuid:fd6be538-5087-4982-9555-d73fcb41c820
Local pid:
pubs:26663
Source identifiers:
26663
Deposit date:
2012-12-19

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