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Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice

Abstract:

The accumulation of adenosine is strongly correlated with the need for sleep and the detection of sleep pressure is antagonised by caffeine. Caffeine also affects the circadian timing system directly and independently of sleep physiology, but how caffeine mediates these effects upon the circadian clock is unclear. Here we identify an adenosine-based regulatory mechanism that allows sleep and circadian processes to interact for the optimisation of sleep/wake timing in mice. Adenosine encode...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-021-22179-z

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Oxford college:
Oriel College
Role:
Author
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Name:
Biotechnology and Biological Sciences Research Council
Grant:
BB/N01992X/1
Publisher:
Nature Research
Journal:
Nature Communications More from this journal
Volume:
12
Article number:
2113
Publication date:
2021-04-09
Acceptance date:
2021-02-18
DOI:
EISSN:
2041-1723
Language:
English
Keywords:
Pubs id:
1170882
Local pid:
pubs:1170882
Deposit date:
2021-04-09

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