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Xist gene regulation at the onset of X inactivation.

Abstract:

The large non-coding RNA Xist is the master regulator of X inactivation. Xist is negatively regulated by its antisense transcript Tsix. This repressive antisense transcription across Xist operates at least in part through the modification of the chromatin environment of the locus. However Tsix is not sufficient to repress Xist in pluripotent cells and there is emerging evidence that transcription factors associated with pluripotency are involved in Tsix-independent repression. This review foc...

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Publication status:
Published

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Publisher copy:
10.1016/j.gde.2009.03.003

Authors


Senner, CE More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Journal:
Current opinion in genetics and development
Volume:
19
Issue:
2
Pages:
122-126
Publication date:
2009-04-05
DOI:
EISSN:
1879-0380
ISSN:
0959-437X
URN:
uuid:fd66707c-9e2e-4f2f-b1c2-76b3a3865bf5
Source identifiers:
100248
Local pid:
pubs:100248

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