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Multivesicular exocytosis in rat pancreatic beta cells.

Abstract:

AIMS/HYPOTHESIS: To establish the occurrence, modulation and functional significance of compound exocytosis in insulin-secreting beta cells. METHODS: Exocytosis was monitored in rat beta cells by electrophysiological, biochemical and optical methods. The functional assays were complemented by three-dimensional reconstruction of confocal imaging, transmission and block face scanning electron microscopy to obtain ultrastructural evidence of compound exocytosis. RESULTS: Compound exocytosis cont...

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Publication status:
Published

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Publisher copy:
10.1007/s00125-011-2400-5

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Journal:
Diabetologia
Volume:
55
Issue:
4
Pages:
1001-1012
Publication date:
2012-04-05
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
URN:
uuid:fd648679-3e1a-43d1-93ac-23a0d0d18521
Source identifiers:
221389
Local pid:
pubs:221389

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