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Journal article

Quantitative study of the effect of tissue microstructure on contraction in a computational model of rat left ventricle.

Abstract:

Tissue microstructure, in particular the alignment of myocytes (fibre direction) and their lateral organisation into sheets, is fundamental to cardiac function. We studied the effect of microstructure on contraction in a computational model of rat left ventricular electromechanics. Different fibre models, globally rule-based or locally optimised to DT-MRI data, were compared, in order to understand whether a subject-specific fibre model would enhance the predictive power of our model with res...

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Publication status:
Published

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Authors


Carapella, V More by this author
Pathmanathan, P More by this author
Lohezic, M More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
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Publisher:
Public Library of Science
Journal:
PloS one
Volume:
9
Issue:
4
Pages:
e92792
Publication date:
2014
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:fd5a9aa4-4706-41e9-b1cf-97899c4547d4
Source identifiers:
458678
Local pid:
pubs:458678
Language:
English

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