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Quantitative study of the effect of tissue microstructure on contraction in a computational model of rat left ventricle.

Abstract:

Tissue microstructure, in particular the alignment of myocytes (fibre direction) and their lateral organisation into sheets, is fundamental to cardiac function. We studied the effect of microstructure on contraction in a computational model of rat left ventricular electromechanics. Different fibre models, globally rule-based or locally optimised to DT-MRI data, were compared, in order to understand whether a subject-specific fibre model would enhance the predictive power of our model with res...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
Publisher:
Public Library of Science
Journal:
PloS one More from this journal
Volume:
9
Issue:
4
Pages:
e92792
Publication date:
2014-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Language:
English
Pubs id:
pubs:458678
UUID:
uuid:fd5a9aa4-4706-41e9-b1cf-97899c4547d4
Local pid:
pubs:458678
Source identifiers:
458678
Deposit date:
2014-08-17

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