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Assessing early therapeutic response to bevacizumab in primary breast cancer using magnetic resonance imaging and gene expression profiles.

Abstract:

Antiangiogenic therapy is a promising approach for the treatment of breast cancer. In practice, however, only a subset of patients who receive antiangiogenic drugs demonstrate a significant response. A key challenge, therefore, is to discover biomarkers that are predictive of response to antiangiogenic therapy. To address this issue, we have designed a window-of-opportunity study in which bevacizumab is administered as a short-term first-line treatment to primary breast cancer patients. Centr...

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Journal:
Journal of the National Cancer Institute. Monographs
Volume:
2011
Issue:
43
Pages:
71-74
Publication date:
2011-01-01
DOI:
EISSN:
1745-6614
ISSN:
1052-6773
URN:
uuid:fd51ba7f-3c5e-4af2-a94c-ff13bbbbfc51
Source identifiers:
245928
Local pid:
pubs:245928

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