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The potential of hybrid antibodies secreted by hybrid-hybridomas in tumour therapy.

Abstract:

Using a simple method for the selection of hybrid cell growth from the cell fusion of pairs of existing hybridoma cell lines, 2 different hybrid-hybridoma cell lines were produced. Both hybrid-hybridomas secreted bi-specific antibody with similar specificity for human CD3 and for mouse Thy-l but in one case the parental antibody isotypes were both IgG2b and in the other case the CD3 antibody was IgG2b and the anti-Thy-l antibody was IgG2c. In a model in vitro system both bi-specific antibodie...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
International journal of cancer. Supplement = Journal international du cancer. Supplement More from this journal
Volume:
2
Pages:
15-17
Publication date:
1988-01-01
ISSN:
0898-6924
Language:
English
Keywords:
Pubs id:
pubs:9279
UUID:
uuid:fd51337a-a9be-4b92-a55c-4540e4329692
Local pid:
pubs:9279
Source identifiers:
9279
Deposit date:
2012-12-19

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