Journal article icon

Journal article

Hinges, swivels and switches: the role of prolines in signalling via transmembrane alpha-helices.

Abstract:

Extracellular signals are transduced across membranes via conformational changes in the transmembrane domains (TMs) of ion channels and G-protein-coupled receptors (GPCRs). Experimental and simulation studies indicate that such conformational switches in transmembrane (alpha-helices can be generated by proline-containing motifs that form molecular hinges. Computational approaches tested on model channel-forming peptides (e.g. alamethicin) reveal functional mechanisms in gap-junction proteins ...

Expand abstract
Publication status:
Published

Actions


Access Document


Journal:
Trends in pharmacological sciences More from this journal
Volume:
21
Issue:
11
Pages:
445-451
Publication date:
2000-11-01
DOI:
EISSN:
1873-3735
ISSN:
0165-6147
Language:
English
Keywords:
Pubs id:
pubs:100860
UUID:
uuid:fd4f0e99-91fb-4941-a1c1-8f7bba103f28
Local pid:
pubs:100860
Source identifiers:
100860
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP