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Preservation of a critical epitope core region is associated with the high degree of flaviviral cross‐reactivity exhibited by a dengue‐specific CD4+ T cell clone

Abstract:

Dengue is a member of the Flaviviridae, a large group of related viruses some of which co‐circulate in certain regions (e.g. dengue and Yellow fever in South America). Immune responses cross‐reactive between different dengue serotypes are important in the pathogenesis of dengue disease but it is not known whether previous infection with one flavivirus might affect the clinical course of subsequent infections with other members of the family. CD4+ T cells have ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/eji.200737699

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
Publisher:
Wiley
Journal:
European Journal of Immunology More from this journal
Volume:
38
Issue:
4
Pages:
1050-1057
Publication date:
2008-04-07
Acceptance date:
2008-02-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Pmid:
18383038
Language:
English
Keywords:
Pubs id:
pubs:34190
UUID:
uuid:fd464945-2eef-47ed-9037-f889f7244194
Local pid:
pubs:34190
Source identifiers:
34190
Deposit date:
2017-07-19

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