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Mechanisms of structure generation during plastic compression of nanofibrillar collagen hydrogel scaffolds: towards engineering of collagen.

Abstract:

Operator control of cell/matrix density of plastically compressed collagen hydrogel scaffolds critically depends on reproducibly limiting the extent of scaffold compaction, as fluid expulsion. A functional model of the compression process is presented, based on the idea that the main fluid-leaving surface (FLS) behaves as an ultrafiltration membrane, allowing fluid (water) out but retaining collagen fibrils to form a cake. We hypothesize that accumulation of collagen at the FLS produces aniso...

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Publication status:
Published

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Publisher copy:
10.1002/term.343

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Journal:
Journal of tissue engineering and regenerative medicine
Volume:
5
Issue:
7
Pages:
505-519
Publication date:
2011-07-05
DOI:
EISSN:
1932-7005
ISSN:
1932-6254
URN:
uuid:fd4586fd-d6c0-4ee3-b378-6fbfe52c8335
Source identifiers:
166599
Local pid:
pubs:166599

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