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Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes.

Abstract:

Adiponectin is strongly inversely associated with insulin resistance and type 2 diabetes, but its causal role remains controversial. We used a Mendelian randomization approach to test the hypothesis that adiponectin causally influences insulin resistance and type 2 diabetes. We used genetic variants at the ADIPOQ gene as instruments to calculate a regression slope between adiponectin levels and metabolic traits (up to 31,000 individuals) and a combination of instrumental variables and summary...

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Publication status:
Published

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Publisher copy:
10.2337/db13-0128

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Journal:
Diabetes
Volume:
62
Issue:
10
Pages:
3589-3598
Publication date:
2013-10-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:fd376590-520a-44d4-a377-1d5ba7bc4b0c
Source identifiers:
421178
Local pid:
pubs:421178

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