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A reliable ex vivo invasion assay of human reticulocytes by Plasmodium vivax.

Abstract:

Currently, there are no reliable RBC invasion assays to guide the discovery of vaccines against Plasmodium vivax, the most prevalent malaria parasite in Asia and South America. Here we describe a protocol for an ex vivo P vivax invasion assay that can be easily deployed in laboratories located in endemic countries. The assay is based on mixing enriched cord blood reticulocytes with matured, trypsin-treated P vivax schizonts concentrated from clinical isolates. The reliability of this assay wa...

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Authors


Russell, B More by this author
Suwanarusk, R More by this author
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Journal:
Blood
Volume:
118
Issue:
13
Pages:
e74-e81
Publication date:
2011-09-29
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:fd3599f8-3677-445e-a7a7-f7425c0ff006
Source identifiers:
166431
Local pid:
pubs:166431

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