Journal article
Structural principles controlling HIV envelope glycosylation
- Abstract:
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The heavily glycosylated, trimeric HIV-1 envelope (Env) protein is the sole viral protein exposed on the HIV-1 virion surface and is thus a main focus of antibody-mediated vaccine development. Dense glycosylation at the outer domain of Env constrains normal enzymatic processing, stalling the glycans at immature oligomannose-type structures. Furthermore, native trimerization imposes additional steric constraints, which generate an extensive ‘trimer-induced mannose patch’. Importantly, the imma...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 772.9KB)
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- Publisher copy:
- 10.1016/j.sbi.2017.03.008
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Authors
Funding
+ Corpus Christi College, Oxford
More from this funder
Funding agency for:
Behrens, A
Grant:
Chris Scanlan Memorial Scholarship
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Current Opinion in Structural Biology Journal website
- Volume:
- 44
- Pages:
- 125-133
- Publication date:
- 2017-03-01
- Acceptance date:
- 2017-03-27
- DOI:
- EISSN:
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1879-033X
- ISSN:
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0959-440X
- Source identifiers:
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687301
Item Description
- Pubs id:
-
pubs:687301
- UUID:
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uuid:fd2b89ea-0a38-456f-934f-6029c4682975
- Local pid:
- pubs:687301
- Deposit date:
- 2017-03-29
Terms of use
- Copyright holder:
- Elsevier Ltd
- Copyright date:
- 2017
- Notes:
- © 2017 Elsevier Ltd. All rights reserved. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: http://10.1016/j.sbi.2017.03.008
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