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Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage.

Abstract:

Hepatitis B virus (HBV) causes chronic infection in more than 350 million people worldwide. It replicates in hepatocytes but is non-cytopathic; liver damage is thought to be immune mediated. Here, we investigated the role of innate immune responses in mediating liver damage in patients with chronic HBV infection. Longitudinal analysis revealed a temporal correlation between flares of liver inflammation and fluctuations in interleukin (IL)-8, interferon (IFN)-alpha, and natural killer (NK) cel...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20061287

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Journal:
Journal of experimental medicine More from this journal
Volume:
204
Issue:
3
Pages:
667-680
Publication date:
2007-03-01
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Language:
English
Keywords:
Pubs id:
pubs:33782
UUID:
uuid:fd0f18c3-5d2e-4e5e-be6a-79188d9372c6
Local pid:
pubs:33782
Source identifiers:
33782
Deposit date:
2012-12-19

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