Journal article icon

Journal article

Targeting ATR in DNA damage response and cancer therapeutics.

Abstract:

The ataxia telangiectasia and Rad3-related (ATR) plays an important role in maintaining genome integrity during DNA replication through the phosphorylation and activation of Chk1 and regulation of the DNA damage response. Preclinical studies have shown that disruption of ATR pathway can exacerbate the levels of replication stress in oncogene-driven murine tumors to promote cell killing. Additionally, inhibition of ATR can sensitise tumor cells to radiation or chemotherapy. Accumulating eviden...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.ctrv.2013.03.002

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Brunner, TB More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Expand authors...
Journal:
Cancer treatment reviews
Volume:
40
Issue:
1
Pages:
109-117
Publication date:
2014-02-05
DOI:
EISSN:
1532-1967
ISSN:
0305-7372
URN:
uuid:fd0d7da0-75d3-4372-934b-9ba6a482d0b8
Source identifiers:
395959
Local pid:
pubs:395959

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP