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Journal article

Targeting ATR in DNA damage response and cancer therapeutics.

Abstract:

The ataxia telangiectasia and Rad3-related (ATR) plays an important role in maintaining genome integrity during DNA replication through the phosphorylation and activation of Chk1 and regulation of the DNA damage response. Preclinical studies have shown that disruption of ATR pathway can exacerbate the levels of replication stress in oncogene-driven murine tumors to promote cell killing. Additionally, inhibition of ATR can sensitise tumor cells to radiation or chemotherapy. Accumulating eviden...

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Publication status:
Published

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Publisher copy:
10.1016/j.ctrv.2013.03.002

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
Cancer treatment reviews More from this journal
Volume:
40
Issue:
1
Pages:
109-117
Publication date:
2014-02-01
DOI:
EISSN:
1532-1967
ISSN:
0305-7372
Language:
English
Keywords:
Pubs id:
pubs:395959
UUID:
uuid:fd0d7da0-75d3-4372-934b-9ba6a482d0b8
Local pid:
pubs:395959
Source identifiers:
395959
Deposit date:
2013-11-16

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