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Journal article

Adenovirus-mediated gene transfer of a secreted decoy human macrophage scavenger receptor (SR-AI) in LDL receptor knock-out mice.

Abstract:

Macrophage scavenger receptors (MSR) play an important role in the pathogenesis of atherosclerosis. Therefore, modulation of MSR activity could have a beneficial effect on atherogenesis. One way to antagonize the function of a cell surface scavenger receptor is to use a soluble decoy receptor. We have constructed a soluble, chimaeric fusion protein that consists of the bovine growth hormone signal sequence and the human MSR AI extracellular domains. This secreted decoy MSR (sMSR) was cloned i...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School, BHF Centre of Research Excellence
Role:
Author
Journal:
Atherosclerosis
Volume:
169
Issue:
1
Pages:
95-103
Publication date:
2003-07-05
DOI:
EISSN:
1879-1484
ISSN:
0021-9150
URN:
uuid:fd0d1cb5-afb6-4555-8ee0-ff9cca4926f6
Source identifiers:
10789
Local pid:
pubs:10789

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