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Heparan sulfate proteoglycan isoforms of the CD44 hyaluronan receptor induced in human inflammatory macrophages can function as paracrine regulators of fibroblast growth factor action.

Abstract:

The CD44 glycoprotein is expressed in multiple isoforms on a variety of cell types where it functions as a receptor for hyaluronan-mediated motility. Recently, interest has centered on CD44 heparan sulfate proteoglycan (HSPG) isoforms because of their potential to sequester heparin-binding growth factors and chemokines. Expression of these isoforms on ectodermal cells has recently been shown to regulate limb morphogenesis via presentation of fibroblast growth factor (FGF) 4/FGF 8 while expres...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.275.11.7964

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Journal:
The Journal of biological chemistry
Volume:
275
Issue:
11
Pages:
7964-7974
Publication date:
2000-03-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:fd0b71ce-430a-4dcb-ae20-59647155e5d3
Source identifiers:
102537
Local pid:
pubs:102537

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