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Journal article

Impact of MHC class I diversity on immune control of immunodeficiency virus replication.

Abstract:

The recent failure of the T-cell-based HIV vaccine trial led by Merck and Co., Inc. prompts the urgent need to refocus on the question of which T-cell responses are required to control HIV replication. The well-described association between the expression of particular MHC class I molecules and successful containment of HIV or, in the macaque model, SIV replication provide a valuable starting point from which to evaluate more precisely what might constitute effective CD8(+) T-cell responses. ...

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Publication status:
Published

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Publisher copy:
10.1038/nri2357

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Institution:
University of Oxford
Department:
Oxford, MSD, Paediatrics
Role:
Author
Journal:
Nature reviews. Immunology
Volume:
8
Issue:
8
Pages:
619-630
Publication date:
2008-08-05
DOI:
EISSN:
1474-1741
ISSN:
1474-1733
URN:
uuid:fcf89f49-e225-4e09-aed3-e01709f94958
Source identifiers:
191193
Local pid:
pubs:191193

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