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Water mediation is essential to nucleation of β-turn formation in peptide folding motifs.

Abstract:
Water-mediated bond formation: The structure of the peptide GPG-NH2 has been investigated in aqueous solution to understand the role of water in the formation of a β-turn. Using a combination of neutron diffraction enhanced by isotopic substitution, NMR spectroscopy, and computer simulations, it was found that water is an essential component to initiate folding in solution.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/anie.201307657

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Name:
Engineering and Physical Sciences Research Council
Publisher:
Wiley-VCH
Journal:
Angewandte Chemie (International ed. in English) More from this journal
Volume:
52
Issue:
49
Pages:
13091-13095
Publication date:
2013-12-01
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
Language:
English
Keywords:
Pubs id:
pubs:433761
UUID:
uuid:fcf239a9-016f-4789-b3ca-50c28ba52f0a
Local pid:
pubs:433761
Source identifiers:
433761
Deposit date:
2013-11-16

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