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Journal article

Purine nucleotide metabolism regulates expression of the human immune ligand MICA

Abstract:

Expression of the cell-surface glycoprotein MHC class I polypeptide-related sequence A (MICA) is induced in dangerous, abnormal, or “stressed” cells, including cancer cells, virus-infected cells, and rapidly proliferating cells. MICA is recognized by the activating immune cell receptor natural killer group 2D (NKG2D), providing a mechanism by which immune cells can identify and potentially eliminate pathological cells. Immune recognition through NKG2D is implicated in cancer, atherosclerosis,...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1074/jbc.m117.809459

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Role:
Author
ORCID:
0000-0001-7148-7096
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Role:
Author
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NIHR Oxford Biomedical Research Centre More from this funder
Publisher:
American Society for Biochemistry and Molecular Biology Publisher's website
Journal:
Journal of Biological Chemistry Journal website
Volume:
293
Issue:
11
Pages:
3913–3924
Publication date:
2017-12-26
Acceptance date:
2017-12-26
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Pubs id:
pubs:813039
URN:
uri:fceb1eee-2db1-40df-b9e6-02afa177f3ba
UUID:
uuid:fceb1eee-2db1-40df-b9e6-02afa177f3ba
Local pid:
pubs:813039

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