- Abstract:
-
Expression of the cell-surface glycoprotein MHC class I polypeptide-related sequence A (MICA) is induced in dangerous, abnormal, or “stressed” cells, including cancer cells, virus-infected cells, and rapidly proliferating cells. MICA is recognized by the activating immune cell receptor natural killer group 2D (NKG2D), providing a mechanism by which immune cells can identify and potentially eliminate pathological cells. Immune recognition through NKG2D is implicated in cancer, atherosclerosis,...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 3.2MB)
-
- Publisher copy:
- 10.1074/jbc.m117.809459
-
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- Publisher:
- American Society for Biochemistry and Molecular Biology Publisher's website
- Journal:
- Journal of Biological Chemistry Journal website
- Volume:
- 293
- Issue:
- 11
- Pages:
- 3913–3924
- Publication date:
- 2017-12-26
- Acceptance date:
- 2017-12-26
- DOI:
- EISSN:
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1083-351X
- ISSN:
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0021-9258
- Pubs id:
-
pubs:813039
- URN:
-
uri:fceb1eee-2db1-40df-b9e6-02afa177f3ba
- UUID:
-
uuid:fceb1eee-2db1-40df-b9e6-02afa177f3ba
- Local pid:
- pubs:813039
- Language:
- English
- Keywords:
- Copyright holder:
- American Society for Biochemistry and Molecular Biology
- Copyright date:
- 2017
- Notes:
- Copyright © 2018, The American Society for Biochemistry and Molecular Biology. This is the publisher's version of the article. The final version is available online from the ASBMB at: 10.1074/jbc.m117.809459
Journal article
Purine nucleotide metabolism regulates expression of the human immune ligand MICA
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NIHR Oxford Biomedical Research Centre
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