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Journal article

Association between analytic strategy and estimates of treatment outcomes in meta-analyses.

Abstract:

IMPORTANCE: A persistent dilemma when performing meta-analyses is whether all available trials should be included in the meta-analysis. OBJECTIVES: To compare treatment outcomes estimated by meta-analysis of all trials and several alternative analytic strategies: single most precise trial (ie, trial with the narrowest confidence interval), meta-analysis restricted to the 25% largest trials, limit meta-analysis (a meta-analysis model adjusted for small-study effect), and meta-analysis restrict...

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Publication status:
Published

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Publisher copy:
10.1001/jama.2014.8166

Authors


Dechartres, A More by this author
Altman, DG More by this author
Trinquart, L More by this author
Boutron, I More by this author
Journal:
JAMA
Volume:
312
Issue:
6
Pages:
623-630
Publication date:
2014-08-05
DOI:
EISSN:
1538-3598
ISSN:
0098-7484
URN:
uuid:fce596bf-c71d-40e9-91c9-59239c84bfb5
Source identifiers:
482044
Local pid:
pubs:482044

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