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The Mon1-Ccz1 GEF activates the Rab7 GTPase Ypt7 via a longin-fold-Rab interface and association with PI3P-positive membranes.

Abstract:

To function in fusion and signaling, Rab GTPases need to be converted into their active GTP form. We previously identified the conserved Mon1-Ccz1 complex as the guanine nucleotide exchange factor (GEF) of the yeast Rab7 GTPase Ypt7. To address the possible GEF mechanism, we generated a homology model of the predicted longin domains of Mon1 and Ccz1 using the Rab-binding surface of the TRAPP complex as a template. On the basis of this, we identified mutations in both yeast Mon1 and Ccz1 that ...

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Publication status:
Published

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Publisher copy:
10.1242/jcs.140921

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Journal:
Journal of cell science
Volume:
127
Issue:
Pt 5
Pages:
1043-1051
Publication date:
2014-03-05
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:fce460fa-6149-47c4-b177-2e848157da63
Source identifiers:
446705
Local pid:
pubs:446705

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