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Downstage migration after neoadjuvant chemoradiotherapy for rectal cancer: the reverse of the Will Rogers phenomenon?

Abstract:

Downstaging after neoadjuvant treatment is increasingly used as a prognostic factor and surrogate endpoint in clinical trials. However, in recent trials of neoadjuvant 5-fluorouracil-based chemoradiotherapy for rectal cancer, downstaging did not translate into a benefit with regard to either disease-free survival (DFS) or overall survival. By analyzing the 10-year outcome data of the German CAO/ARO/AIO-94 phase 3 trial, the authors demonstrated that significantly fewer patients had poor progn...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/cncr.29260

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Publisher:
Wiley
Journal:
Cancer More from this journal
Volume:
121
Issue:
11
Pages:
1724-1727
Publication date:
2015-06-01
DOI:
EISSN:
1097-0142
ISSN:
0008-543X
Language:
English
Keywords:
Pubs id:
pubs:505562
UUID:
uuid:fce06769-7903-479b-bab6-b4423455c1ec
Local pid:
pubs:505562
Source identifiers:
505562
Deposit date:
2015-11-23

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