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Journal article

Crystal structure of the RNA-dependent RNA polymerase from influenza C virus.

Abstract:

Negative-sense RNA viruses, such as influenza, encode large, multidomain RNA-dependent RNA polymerases that can both transcribe and replicate the viral RNA genome. In influenza virus, the polymerase (FluPol) is composed of three polypeptides: PB1, PB2 and PA/P3. PB1 houses the polymerase active site, whereas PB2 and PA/P3 contain, respectively, cap-binding and endonuclease domains required for transcription initiation by cap-snatching. Replication occurs through de novo initiation and involve...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/nature15525

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Biology
Role:
Author
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Department:
Oxford, MSD, NDM, Structural Biology
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Funding agency for:
Hengrung, N
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Funding agency for:
Serna Martin, I
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Journal website
Volume:
527
Issue:
7576
Pages:
114-117
Publication date:
2015-11-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:fcd66e42-65c2-49b1-b677-2b5363632f4e
Source identifiers:
575132
Local pid:
pubs:575132

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