Negative-sense RNA viruses, such as influenza, encode large, multidomain RNA-dependent RNA polymerases that can both transcribe and replicate the viral RNA genome. In influenza virus, the polymerase (FluPol) is composed of three polypeptides: PB1, PB2 and PA/P3. PB1 houses the polymerase active site, whereas PB2 and PA/P3 contain, respectively, cap-binding and endonuclease domains required for transcription initiation by cap-snatching. Replication occurs through de novo initiation and involve...Expand abstract
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- Peer reviewed
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- Macmillan Publishers
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- © 2015 Macmillan Publishers Limited. All rights reserved. The final version is available online from Nature Publishing Group at: [10.1038/nature15525].
Crystal structure of the RNA-dependent RNA polymerase from influenza C virus.
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