- Abstract:
-
Negative-sense RNA viruses, such as influenza, encode large, multidomain RNA-dependent RNA polymerases that can both transcribe and replicate the viral RNA genome. In influenza virus, the polymerase (FluPol) is composed of three polypeptides: PB1, PB2 and PA/P3. PB1 houses the polymerase active site, whereas PB2 and PA/P3 contain, respectively, cap-binding and endonuclease domains required for transcription initiation by cap-snatching. Replication occurs through de novo initiation and involve...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Publisher copy:
- 10.1038/nature15525
-
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- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Journal website
- Volume:
- 527
- Issue:
- 7576
- Pages:
- 114-117
- Publication date:
- 2015-11-05
- DOI:
- EISSN:
-
1476-4687
- ISSN:
-
0028-0836
- URN:
-
uuid:fcd66e42-65c2-49b1-b677-2b5363632f4e
- Source identifiers:
-
575132
- Local pid:
- pubs:575132
- Language:
- English
- Keywords:
- Copyright holder:
- Macmillan Publishers
- Copyright date:
- 2015
- Notes:
- © 2015 Macmillan Publishers Limited. All rights reserved. The final version is available online from Nature Publishing Group at: [10.1038/nature15525].
Journal article
Crystal structure of the RNA-dependent RNA polymerase from influenza C virus.
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