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An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4.

Abstract:

Toll-like receptors (TLRs) mediate responses to pathogen-associated molecules as part of the vertebrate innate immune response to infection. Receptor dimerization is coupled to downstream signal transduction by the recruitment of a post-receptor complex containing the adaptor protein MyD88 and the IRAK protein kinases. In this work, we show that the death domains of human MyD88 and IRAK-4 assemble into closed complexes having unusual stoichiometries of 7:4 and 8:4, the Myddosome. Formation of...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m109.022392

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Journal:
Journal of biological chemistry More from this journal
Volume:
284
Issue:
37
Pages:
25404-25411
Publication date:
2009-09-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258

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