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CCR5 promoter polymorphisms in a Kenyan perinatal human immunodeficiency virus type 1 cohort: association with increased 2-year maternal mortality.

Abstract:

The CCR5 chemokine receptor acts as a coreceptor with CD4 to permit infection by primary macrophage-tropic human immunodeficiency virus type 1 (HIV-1) strains. The CCR5Delta32 mutation, which is associated with resistance to infection in homozygous individuals and delayed disease progression in heterozygous individuals, is rare in Africa, where the HIV-1 epidemic is growing rapidly. Several polymorphisms in the promoter region of CCR5 have been identified, the clinical and functional relevanc...

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Publication status:
Published

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Publisher copy:
10.1086/321006

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Journal:
Journal of infectious diseases More from this journal
Volume:
184
Issue:
1
Pages:
89-92
Publication date:
2001-07-01
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Language:
English
Keywords:
Pubs id:
pubs:14364
UUID:
uuid:fcd00814-df6f-4683-9201-1d477a7cc331
Local pid:
pubs:14364
Source identifiers:
14364
Deposit date:
2012-12-19

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