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Journal article

Added value of combining methotrexate with a biological agent compared to biological monotherapy in rheumatoid arthritis patients: A systematic review and meta-analysis of randomised trials

Abstract:

Objectives: To assess the efficacy and safety of methotrexate (MTX) in combination with an approved biological agent compared to biological monotherapy, in the management of patients with rheumatoid arthritis (RA).

Methods: MEDLINE, EMBASE, CENTRAL and other sources were searched for randomised trials evaluating a biological agent plus MTX versus the same biological agent in monotherapy. Co-primary outcomes were ACR50 and the number of patients who ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.semarthrit.2018.10.002

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Oxford college:
St Peter's College
Role:
Author
ORCID:
0000-0001-7766-6167
Publisher:
Elsevier
Journal:
Seminars in Arthritis and Rheumatism More from this journal
Volume:
48
Issue:
6
Pages:
958-966
Publication date:
2018-10-09
Acceptance date:
2018-10-01
DOI:
EISSN:
1532-866X
ISSN:
0049-0172
Keywords:
Pubs id:
pubs:923505
UUID:
uuid:fcc78369-09a8-4fdd-a355-97149754dd9d
Local pid:
pubs:923505
Source identifiers:
923505
Deposit date:
2018-10-04

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