- Abstract:
-
Both the anticonvulsant and sedative effects of diazepam (5 mg/kg) were reversed by subsequent administration of the suggested specific benzodiazepine antagonist Ro 15-1788. In contrast neither the seizure threshold raising or sedative effect of melatonin (200 mg/kg) was reversed by Ro 15-1788. Ro 15-1788 had no effect on the convulsant action of the benzodiazepine Ro 05-3663. These data therefore argue against the suggestion that melatonin produces its sedative and anticonvulsant effects in ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1007/bf00428169
-
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- Publisher:
- Springer-Verlag
- Journal:
- Psychopharmacology
- Volume:
- 78
- Issue:
- 3
- Pages:
- 293-295
- Publication date:
- 1982
- DOI:
- EISSN:
-
1432-2072
- ISSN:
-
0033-3158
- URN:
-
uuid:fcc6faa9-5adf-4ce5-aef0-c636b2d5fc8a
- Source identifiers:
-
185960
- Local pid:
- pubs:185960
- Copyright date:
- 1982
Journal article
Using Ro 15-1788 to investigate the benzodiazepine receptor in vivo: studies on the anticonvulsant and sedative effect of melatonin and the convulsant effect of the benzodiazepine Ro 05-3663.
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