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Using Ro 15-1788 to investigate the benzodiazepine receptor in vivo: studies on the anticonvulsant and sedative effect of melatonin and the convulsant effect of the benzodiazepine Ro 05-3663.

Abstract:

Both the anticonvulsant and sedative effects of diazepam (5 mg/kg) were reversed by subsequent administration of the suggested specific benzodiazepine antagonist Ro 15-1788. In contrast neither the seizure threshold raising or sedative effect of melatonin (200 mg/kg) was reversed by Ro 15-1788. Ro 15-1788 had no effect on the convulsant action of the benzodiazepine Ro 05-3663. These data therefore argue against the suggestion that melatonin produces its sedative and anticonvulsant effects in ...

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Publication status:
Published

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Publisher copy:
10.1007/bf00428169

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Publisher:
Springer-Verlag
Journal:
Psychopharmacology
Volume:
78
Issue:
3
Pages:
293-295
Publication date:
1982
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
URN:
uuid:fcc6faa9-5adf-4ce5-aef0-c636b2d5fc8a
Source identifiers:
185960
Local pid:
pubs:185960

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