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Risedronate slows or partly reverses cortical and trabecular microarchitectural deterioration in postmenopausal women.

Abstract:

During early menopause, steady-state bone remodeling is perturbed; the number of basic multicellular units (BMUs) excavating cavities upon the endosteal surface exceeds the number (generated before menopause) concurrently refilling. Later in menopause, steady-state is restored; the many BMUs generated in early menopause refill as similarly large numbers of BMUs concurrently excavate new cavities. We hypothesized that risedronate reduces the number of cavities excavated. However, in younger po...

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Publication status:
Published

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Publisher copy:
10.1002/jbmr.2101

Authors


Chapurlat, R More by this author
Cheung, AM More by this author
Felsenberg, D More by this author
LaRoche, M More by this author
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Journal:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Volume:
29
Issue:
2
Pages:
380-388
Publication date:
2014-02-05
DOI:
EISSN:
1523-4681
ISSN:
0884-0431
URN:
uuid:fcc1a0e5-e994-4b47-8fc1-b4eda6b58b64
Source identifiers:
473388
Local pid:
pubs:473388

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