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Journal article

Rational design of a novel calcium-binding site adjacent to the ligand-binding site on CD2 increases its CD48 affinity.

Abstract:

Electrostatic interactions are important for molecular recognition processes including Ca2+-binding and cell adhesion. To understand these processes, we have successfully introduced a novel Ca2+-binding site into the non-Ca2+-dependent cell adhesion protein CD2 using our criteria that are specifically tailored to the structural and functional properties of the protein environment and charged adhesion surface. This designed site with ligand residues exclusively from the beta-sheets selectively...

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Publication status:
Published

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Publisher copy:
10.1110/ps.073328208

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Journal:
Protein science : a publication of the Protein Society
Volume:
17
Issue:
3
Pages:
439-449
Publication date:
2008-03-05
DOI:
EISSN:
1469-896X
ISSN:
0961-8368
URN:
uuid:fcb3c639-ccc7-40ce-baa1-0c9687e397d1
Source identifiers:
14463
Local pid:
pubs:14463

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