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Journal article

Reversible infertility in male mice after oral administration of alkylated imino sugars: a nonhormonal approach to male contraception.

Abstract:

During mammalian spermatogenesis, male germ cells undergo a dramatic transformation, which includes a change of shape, nuclear condensation, and development of specialised structures, such as an acrosome, and a flagellum with a mitochondrial sheath. We have found a previously undescribed pharmacological approach to intervene in these events. After oral administration of the alkylated imino sugar N-butyldeoxynojirimycin (NB-DNJ) to mice, epididymal spermatozoa displayed a spectrum of abnormal ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.262586099

Authors


van der Spoel, AC More by this author
Jeyakumar, M More by this author
Butters, TD More by this author
Charlton, HM More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
99
Issue:
26
Pages:
17173-17178
Publication date:
2002-12-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:fcb31551-8bcc-4ec4-9f6a-e97e1789efea
Source identifiers:
100979
Local pid:
pubs:100979

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