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Immune surveillance against a solid tumor fails because of immunological ignorance.

Abstract:

Many peripheral solid tumors such as sarcomas and carcinomas express tumor-specific antigens that can serve as targets for immune effector T cells. Nevertheless, overall immune surveillance against such tumors seems relatively inefficient. We studied immune surveillance against a s.c. sarcoma expressing a characterized viral tumor antigen. Surprisingly, the tumor cells were capable of inducing a protective cytotoxic T cell response if transferred as a single-cell suspension. However, if they ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.96.5.2233

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Role:
Author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
96
Issue:
5
Pages:
2233-2238
Publication date:
1999-03-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:fcb0a541-776f-45aa-b04a-77630841cb11
Source identifiers:
10739
Local pid:
pubs:10739

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