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Blockade of endogenous opioid neurotransmission enhances acquisition of conditioned fear in humans.

Abstract:

The endogenous opioid system is involved in fear learning in rodents, as opioid agonists attenuate and opioid antagonists facilitate the acquisition of conditioned fear. It has been suggested that an opioidergic signal, which is engaged through conditioning and acts inhibitory on unconditioned stimulus input, is the source of these effects. To clarify whether blockade of endogenous opioid neurotransmission enhances acquisition of conditioned fear in humans, and to elucidate the neural underpi...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
28
Issue:
21
Pages:
5465-5472
Publication date:
2008-05-05
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:fca9d8a2-44ee-4e6d-b2bb-e6f0cdebbaec
Source identifiers:
240983
Local pid:
pubs:240983

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