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A peptide encoded by human gene MAGE-3 and presented by HLA-A2 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE-3.

Abstract:

The human MAGE-3 gene is expressed in many tumors of several histological types but it is silent in normal tissues, with the exception of testis. Antigens encoded by MAGE-3 may, therefore, be useful targets for specific anti-tumor immunization of cancer patients. We reported previously that MAGE-3 codes for an antigenic peptide recognized on a melanoma cell line by autologous cytolytic T lymphocytes (CTL) restricted by HLA-A1. Here we report that the MAGE-3 gene also codes for another antigen...

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Publication status:
Published

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Publisher copy:
10.1002/eji.1830241218

Authors


van der Bruggen, P More by this author
Gajewski, T More by this author
Coulie, PG More by this author
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Journal:
European journal of immunology
Volume:
24
Issue:
12
Pages:
3038-3043
Publication date:
1994-12-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:fc9e4a69-a1b2-4ec1-a275-178f8aa6d09c
Source identifiers:
72155
Local pid:
pubs:72155

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