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Journal article

DNA repair capacity as a possible biomarker of breast cancer risk in female BRCA1 mutation carriers.

Abstract:

The BRCA1 gene product helps to maintain genomic integrity through its participation in the cellular response to DNA damage: specifically, the repair of double-stranded DNA breaks. An impaired cellular response to DNA damage is a plausible mechanism whereby BRCA1 mutation carriers are at increased risk of breast cancer. Hence, an individual's capacity to repair DNA may serve as a useful biomarker of breast cancer risk. The overall aim of the current study was to identify a biomarker of DNA re...

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Publication status:
Published

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Publisher copy:
10.1038/sj.bjc.6603528

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
British journal of cancer More from this journal
Volume:
96
Issue:
1
Pages:
118-125
Publication date:
2007-01-01
DOI:
EISSN:
1532-1827
ISSN:
0007-0920

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