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Journal article

Control of autoimmunity by "epitope theft".

Abstract:

We all possess T cells with autoaggressive potential. Knowledge of their regulation is crucial for elucidating pathogenetic pathways and designing effective treatments for autoimmune diseases. A novel mechanism of T-cell silencing--in an autoimmune model--has recently been identified and is termed "epitope theft". The "thieves" are naive CD8+ T cells, which apparently "steal" MHC-class-I-antigen complexes from antigen-presenting cells (APCs). The deprived APCs can no longer activate other pot...

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Publication status:
Published

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Authors


Taylor, AM More by this author
Willcox, N More by this author
Journal:
Trends in molecular medicine
Volume:
11
Issue:
1
Pages:
1-4
Publication date:
2005-01-05
DOI:
EISSN:
1471-499X
ISSN:
1471-4914
URN:
uuid:fc97b82b-286b-4228-a17e-0ff84cf1c13b
Source identifiers:
196767
Local pid:
pubs:196767

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