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Targeting of viral interleukin-10 with an antibody fragment specific to damaged arthritic cartilage improves its therapeutic potency.

Abstract:

INTRODUCTION: We previously demonstrated that a single-chain fragment variable (scFv) specific to collagen type II (CII) posttranslationally modified by reactive oxygen species (ROS) can be used to target anti-inflammatory therapeutics specifically to inflamed arthritic joints. The objective of the present study was to demonstrate the superior efficacy of anti-inflammatory cytokines when targeted to inflamed arthritic joints by the anti-ROS modified CII (anti-ROS-CII) scFv in a mouse model of...

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Publisher copy:
10.1186/ar4613

Authors


Publisher:
BioMed Central
Journal:
Arthritis research and therapy More from this journal
Volume:
16
Issue:
4
Pages:
R151
Publication date:
2014-01-01
DOI:
EISSN:
1478-6362
ISSN:
1478-6354
Language:
English
Pubs id:
pubs:478465
UUID:
uuid:fc855887-63cf-485d-98a7-72f96d4fc10c
Local pid:
pubs:478465
Source identifiers:
478465
Deposit date:
2014-08-27

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