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Journal article

Block of ATP-sensitive K+ channels in isolated mouse pancreatic beta-cells by 2,3-butanedione monoxime.

Abstract:

1. The patch-clamp technique has been used to examine the action of the chemical phosphatase 2,3-butanedione monoxime (BDM) on ATP-sensitive K+ channels (KATP-channels) from mouse isolated pancreatic beta-cells in the absence of ATP and Mg2+. 2. BDM reversibly inhibited whole-cell KATP-currents with a concentration for half maximal inhibition (K(i)) of 15 +/- 1 mM and a Hill coefficient (n) of 2.5 +/- 0.2 (n = 4). 3. In outside-out patches, external BDM reversibly reduced the activity of sing...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
British journal of pharmacology More from this journal
Volume:
112
Issue:
1
Pages:
143-149
Publication date:
1994-05-01
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
Language:
English
Keywords:
Pubs id:
pubs:113655
UUID:
uuid:fc852347-ef4a-4f54-a454-4c41a0c74ca0
Local pid:
pubs:113655
Source identifiers:
113655
Deposit date:
2012-12-19

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