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Dynamic interactions in malaria: host heterogeneity meets parasite polymorphism.

Abstract:

The spectrum of disease severity in Plasmodium falciparum malaria can be attributed to heterogeneity in parasite virulence or to heterogeneity in host factors. However, the two are not necessarily separate explanations for the same phenomena: they may actually complement each other. The conjoint effects of host and parasite heterogeneity can serve to explain certain intriguing epidemiological observations, such as, why there is a reduction in incidence of severe malaria in certain host genoty...

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Publication status:
Published

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Publisher copy:
10.1098/rspb.1995.0147

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
Journal:
Proceedings. Biological sciences / The Royal Society
Volume:
261
Issue:
1362
Pages:
271-277
Publication date:
1995-09-05
DOI:
EISSN:
1471-2954
ISSN:
0962-8452
URN:
uuid:fc83ce71-5697-4a04-88a5-75da535d377d
Source identifiers:
35902
Local pid:
pubs:35902

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