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Mechanisms of cardiac iron homeostasis and their importance to heart function

Abstract:

Heart disease is a common manifestation in conditions of iron imbalance. Normal heart function requires coupling of iron supply for oxidative phosphorylation and redox signalling with tight control of intracellular iron to below levels at which excessive ROS are generated. Iron supply to the heart is dependent on systemic iron availability which is controlled by the systemic hepcidin/ferroportin axis. Intracellular iron in cardiomyocytes is controlled in part by the iron regulatory proteins I...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.freeradbiomed.2018.08.010

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Name:
British Heart Foundation
Grant:
FS/12/63/29895
Publisher:
Elsevier
Journal:
Free Radical Biology and Medicine More from this journal
Publication date:
2018-08-11
Acceptance date:
2018-08-10
DOI:
EISSN:
1873-4596
ISSN:
0891-5849
Pmid:
30107217
Language:
English
Keywords:
Pubs id:
pubs:909986
UUID:
uuid:fc7c01a8-afda-4925-9911-039dc73b18dd
Local pid:
pubs:909986
Source identifiers:
909986
Deposit date:
2018-10-30

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