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Loop-mediated isothermal amplification method targeting the TTS1 gene cluster for detection of Burkholderia pseudomallei and diagnosis of melioidosis.

Abstract:

Melioidosis is a severe infection caused by Burkholderia pseudomallei. The timely implementation of effective antimicrobial treatment requires rapid diagnosis. Loop-mediated isothermal amplification (LAMP) targeting the TTS1 gene cluster was developed for the detection of B. pseudomallei. LAMP was sensitive and specific for the laboratory detection of this organism. The lower limit of detection was 38 genomic copies per reaction, and LAMP was positive for 10 clinical B. pseudomallei isolates ...

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Publication status:
Published

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Publisher copy:
10.1128/jcm.01817-07

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
Journal:
Journal of clinical microbiology More from this journal
Volume:
46
Issue:
2
Pages:
568-573
Publication date:
2008-02-01
DOI:
EISSN:
1098-660X
ISSN:
0095-1137
Language:
English
Keywords:
Pubs id:
pubs:19903
UUID:
uuid:fc74d9d5-d1dd-49af-a476-af358dbe2df3
Local pid:
pubs:19903
Source identifiers:
19903
Deposit date:
2012-12-19

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