Journal article icon

Journal article

Regulation of thymocyte trafficking by Tagap, a GAP domain protein linked to human autoimmunity.

Abstract:

Multiple autoimmune pathologies are associated with single-nucleotide polymorphisms of the human gene TAGAP, which encodes TAGAP, a guanosine triphosphatase (GTPase)-activating protein. We showed in mice that Tagap-mediated signaling by the sema3E/plexin-D1 ligand-receptor complex attenuates thymocytes' adhesion to the cortex through their β1-containing integrins. By promoting thymocyte detachment within the cortex of the thymus, Tagap-mediated signaling enabled their translocation to the med...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1126/scisignal.aan8799

Authors


More by this author
Role:
Author
ORCID:
0000-0002-9478-9609
More by this author
Role:
Author
ORCID:
0000-0002-6514-8239
More by this author
Role:
Author
ORCID:
0000-0001-9941-6038
More by this author
Role:
Author
ORCID:
0000-0002-5598-4292
More by this author
Role:
Author
ORCID:
0000-0001-9655-622X
More from this funder
Name:
NIH HHS
Grant:
S10 OD021740
More from this funder
Name:
Wellcome Trust
Grant:
WT094296MA
More from this funder
Name:
NIAID NIH HHS
Grant:
R01 AI115698
More from this funder
Name:
NIDDK NIH HHS
Grant:
P30 DK036836
Publisher:
American Association for the Advancement of Science
Journal:
Science Signaling More from this journal
Volume:
11
Issue:
534
Publication date:
2018-06-12
Acceptance date:
2018-05-24
DOI:
EISSN:
1937-9145
ISSN:
1945-0877
Pmid:
29895617
Language:
English
Pubs id:
pubs:857589
UUID:
uuid:fc6f8e4c-89f1-449b-b458-9be67f9c2b61
Local pid:
pubs:857589
Source identifiers:
857589
Deposit date:
2019-06-21

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP