- Abstract:
-
PURPOSE: Virus-directed enzyme prodrug therapy depends on selective delivery of virus encoding a prodrug-activating enzyme to tumor, followed by systemic treatment with prodrug to achieve high levels of the activated cytotoxic at the intended site of action. The use of the bacterial enzyme nitroreductase to activate CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide) to a short lived, highly toxic DNA cross-linking agent has been demonstrated in tumor xenografts. In this study, we report the fir...
Expand abstract - Publisher copy:
- 10.1200/jco.2004.10.005
-
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- Journal:
- Journal of clinical oncology : official journal of the American Society of Clinical Oncology
- Volume:
- 22
- Issue:
- 9
- Pages:
- 1546-1552
- Publication date:
- 2004-05-29
- DOI:
- EISSN:
-
1527-7755
- ISSN:
-
0732-183X
- URN:
-
uuid:fc6642aa-844f-4f15-8435-79ab363fde4c
- Source identifiers:
-
371627
- Local pid:
- pubs:371627
- Language:
- English
- Keywords:
- Copyright date:
- 2004
Journal article
Virus-directed enzyme prodrug therapy: intratumoral administration of a replication-deficient adenovirus encoding nitroreductase to patients with resectable liver cancer.
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