Journal article icon

Journal article

Virus-directed enzyme prodrug therapy: intratumoral administration of a replication-deficient adenovirus encoding nitroreductase to patients with resectable liver cancer.

Abstract:

PURPOSE: Virus-directed enzyme prodrug therapy depends on selective delivery of virus encoding a prodrug-activating enzyme to tumor, followed by systemic treatment with prodrug to achieve high levels of the activated cytotoxic at the intended site of action. The use of the bacterial enzyme nitroreductase to activate CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide) to a short lived, highly toxic DNA cross-linking agent has been demonstrated in tumor xenografts. In this study, we report the fir...

Expand abstract

Actions


Access Document


Publisher copy:
10.1200/jco.2004.10.005

Authors


Expand authors...
Journal:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Volume:
22
Issue:
9
Pages:
1546-1552
Publication date:
2004-05-29
DOI:
EISSN:
1527-7755
ISSN:
0732-183X
URN:
uuid:fc6642aa-844f-4f15-8435-79ab363fde4c
Source identifiers:
371627
Local pid:
pubs:371627

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP