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XRad17 is required for the activation of XChk1 but not XCds1 during checkpoint signaling in Xenopus.

Abstract:

The DNA damage/replication checkpoints act by sensing the presence of damaged DNA or stalled replication forks and initiate signaling pathways that arrest cell cycle progression. Here we report the cloning and characterization of Xenopus orthologues of the RFCand PCNA-related checkpoint proteins. XRad17 shares regions of homology with the five subunits of Replication factor C. XRad9, XRad1, and XHus1 (components of the 9-1-1 complex) all show homology to the DNA polymerase processivity factor...

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Publisher copy:
10.1091/mbc.e03-03-0138

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Puligilla, C More by this author
Murray, JM More by this author
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Journal:
Molecular biology of the cell
Volume:
14
Issue:
9
Pages:
3898-3910
Publication date:
2003-09-05
DOI:
EISSN:
1939-4586
ISSN:
1059-1524
URN:
uuid:fc6640e5-62f5-4cd7-b16c-65b6581a2419
Source identifiers:
399296
Local pid:
pubs:399296

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