Journal article icon

Journal article

Double negative regulatory T cells in transplantation and autoimmunity: recent progress and future directions.

Abstract:

T lymphocytes bearing the αβ T cell receptor (TCR) but lacking CD4, CD8, and markers of natural killer (NK) cell differentiation are known as 'double-negative' (DN) T cells and have been described in both humans and rodent models. We and others have shown that DN T cells can act as regulatory T cells (Tregs) that are able to prevent allograft rejection, graft-versus-host disease, and autoimmune diabetes. In the last few years, new data have revealed evidence of DN Treg function in vivo in rod...

Expand abstract

Actions


Access Document


Publisher copy:
10.1093/jmcb/mjr043

Authors


Journal:
Journal of molecular cell biology
Volume:
4
Issue:
1
Pages:
48-58
Publication date:
2012-02-05
DOI:
EISSN:
1759-4685
ISSN:
1674-2788
URN:
uuid:fc616878-4124-4466-a866-b1179f30df32
Source identifiers:
400590
Local pid:
pubs:400590

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP