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Genomic organization of mouse and human Bruton's agammaglobulinemia tyrosine kinase (Btk) loci.

Abstract:

Btk is a cytoplasmic protein tyrosine kinase (PTK) that has been directly implicated in the pathogenesis of X-linked agammaglobulinaemia (XLA) in humans and X-linked immunodeficiency (Xid) in mice. We have isolated phage and cosmid clones that allowed us to deduce the genomic structure of mouse and human Btk loci. The mouse and human genes are contained within genomic regions that span approximately 43.5 kb and 37.5 kb, respectively. Both loci contain 18 coding exons ranging between 55 and 56...

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Journal:
Journal of Immunology More from this journal
Volume:
153
Issue:
12
Pages:
5607-5617
Publication date:
1994-12-01
EISSN:
1550-6606
ISSN:
0022-1767
Language:
English
Keywords:
Pubs id:
pubs:374935
UUID:
uuid:fc6137a3-0c4c-4619-b19d-cc26f89b5030
Local pid:
pubs:374935
Source identifiers:
374935
Deposit date:
2013-11-17

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