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Journal article

Generation of a triple insert live avian herpesvirus vectored vaccine using CRISPR/Cas9-based gene editing

Abstract:

Herpesvirus of turkeys (HVT), used originally as a vaccine against Marek's disease (MD), has recently been shown to be a highly effective viral vector for generation of recombinant vaccines that deliver protective antigens of other avian pathogens. Until the recent launch of commercial HVT-vectored dual insert vaccines, most of the HVT-vectored vaccines in the market carry a single foreign gene and are usually developed with slow and less efficient conventional recombination methods. There is...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
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Name:
Biotechnology and Biological Sciences Research Council
Grant:
BB/P016472/1, BB/L014262/1, BBS/E/I/00007032 and BB/R007896/1
Publisher:
MDPI
Journal:
Vaccines More from this journal
Volume:
8
Issue:
1
Pages:
97
Publication date:
2020-02-21
Acceptance date:
2020-02-19
DOI:
EISSN:
2076-393X
ISSN:
2076-393X
Pmid:
32098149
Language:
English
Keywords:
Pubs id:
1090487
Local pid:
pubs:1090487
Deposit date:
2020-04-14

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