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The inner and outer compartments of mitochondria are sites of distinct cAMP/PKA signaling dynamics.

Abstract:

Cyclic AMP (cAMP)-dependent phosphorylation has been reported to exert biological effects in both the mitochondrial matrix and outer mitochondrial membrane (OMM). However, the kinetics, targets, and effectors of the cAMP cascade in these organellar domains remain largely undefined. Here we used sensitive FRET-based sensors to monitor cAMP and protein kinase A (PKA) activity in different mitochondrial compartments in real time. We found that cytosolic cAMP did not enter the matrix, except duri...

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Publisher copy:
10.1083/jcb.201303159

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More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Journal of cell biology More from this journal
Volume:
202
Issue:
3
Pages:
453-462
Publication date:
2013-08-01
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
Language:
English
Keywords:
Pubs id:
pubs:416531
UUID:
uuid:fc5a02b3-7be0-42a2-ac48-8b43ae374419
Local pid:
pubs:416531
Source identifiers:
416531
Deposit date:
2013-11-16

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