Journal article icon

Journal article

Coalescent methods for fine-scale disease-gene mapping.

Abstract:

Fine-scale mapping methods have been developed to localize functional polymorphisms within large candidate regions identified from previous linkage and/or association studies. Population-based association fine-mapping methods utilize linkage disequilibrium of alleles at high-density marker single-nucleotide polymorphisms with the functional polymorphism, generated as the result of shared ancestry of individuals within the population. Here, we review fine-mapping methods that model the shared ...

Expand abstract

Actions


Access Document


Publisher copy:
10.1007/978-1-59745-389-9_9

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
Journal:
Methods in molecular biology (Clifton, N.J.)
Volume:
376
Pages:
123-140
Publication date:
2007-01-01
DOI:
EISSN:
1940-6029
ISSN:
1064-3745
URN:
uuid:fc544ce2-ce85-4182-bbcd-cf1d9c034bdf
Source identifiers:
34030
Local pid:
pubs:34030

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP