- Abstract:
-
Fine-scale mapping methods have been developed to localize functional polymorphisms within large candidate regions identified from previous linkage and/or association studies. Population-based association fine-mapping methods utilize linkage disequilibrium of alleles at high-density marker single-nucleotide polymorphisms with the functional polymorphism, generated as the result of shared ancestry of individuals within the population. Here, we review fine-mapping methods that model the shared ...
Expand abstract - Publisher copy:
- 10.1007/978-1-59745-389-9_9
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- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Volume:
- 376
- Pages:
- 123-140
- Publication date:
- 2007-01-01
- DOI:
- EISSN:
-
1940-6029
- ISSN:
-
1064-3745
- URN:
-
uuid:fc544ce2-ce85-4182-bbcd-cf1d9c034bdf
- Source identifiers:
-
34030
- Local pid:
- pubs:34030
- Language:
- English
- Keywords:
- Copyright date:
- 2007
Journal article
Coalescent methods for fine-scale disease-gene mapping.
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