- Abstract:
-
Hypercapnia has been shown in animal experiments to induce pulmonary hypertension. This study measured the sensitivity and time course of the human pulmonary vascular response to sustained (4 h) hypercapnia and hypocapnia. Twelve volunteers undertook three protocols: 1) 4-h euoxic (end-tidal Po(2) = 100 Torr) hypercapnia (end-tidal Pco(2) was 10 Torr above normal), followed by 2 h of recovery with euoxic eucapnia; 2) 4-h euoxic hypocapnia (end-tidal Pco(2) was 10 Torr below normal) followed b...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1152/japplphysiol.00890.2002
-
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- Journal:
- Journal of applied physiology (Bethesda, Md. : 1985)
- Volume:
- 94
- Issue:
- 4
- Pages:
- 1543-1551
- Publication date:
- 2003-04-05
- DOI:
- EISSN:
-
1522-1601
- ISSN:
-
8750-7587
- URN:
-
uuid:fc5353ac-6d72-476a-b738-a58819357524
- Source identifiers:
-
114247
- Local pid:
- pubs:114247
- Copyright date:
- 2003
Journal article
Human pulmonary vascular response to 4 h of hypercapnia and hypocapnia measured using Doppler echocardiography.
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